Chemical Proteomics Reveals

New Targets of Cysteine

Sulfinic Acid Reductase

Nat Chem Biol 2018

Our Commitment to Diversity

My lab welcomes students, postdocs and visiting scholars regardless race, religion, gender identification, sexual orientation, age, or disability status. The more reflective of society’s diversity the lab is, the better we are. It is through diverse perspectives and abilities that we see all possible answers to a problem. 

Gupta, V.; Yang, J.; Liebler, D.; Carroll, K. S. J. Am. Chem. Soc. 2017, DOI: 10.1021/jacs.7b01791

Functional site discovery in a sulphur metabolism enzyme using directed evolution

Paritala, H.; Palde, P. B.; Carroll, K. S. ChemBioChem 2016, 17(19): 1873-8, PMID27411165

Molecular basis for redox activation of epidermal growth factor receptor kinase

Truong, T. H.; Ung, P. M.; Paulsen, C. E.; Prakash, P. B.; Schlessinger, A.; Carroll, K. S. Cell Chem. Biol. 2016, 23(7): 837-48, PMC4958504.

An immunochemical approach to detect oxidized protein tyrosine phosphatases using a selective C-nucleophile tag

Garcia, F. J.; Carroll, K. S. Mol. Biosystems 2016, 12(6): 1790-8, PMC4879066.

Reactivity, selectivity, and stability in sulfenic acid detection: A comparative study of nucleophilic and electrophilic probes

Gupta, V.; Carroll, K. S. Bioconj. Chem. 2016, 27(5): 1411-8, PMC4886738.

Rational design of reversible and irreversible cysteine sulfenic acid-targeted linear C-nucleophiles

Gupta, V.; Carroll, K. S. Chem. Comm. 2016, 52(16): 3414-7, PMC4830130.

First-in-class inhibitors of sulfur metabolism with bactericidal activity against non-replicating M. tuberculosis

Palde, P. B.; Bhaskar, A.; Pedró Rosa, L. E.; Madoux, F.; Chase, P. Gupta, V.; Spicer, T.; Scampavia, L.; Singh, A.; Carroll, K. S. ACS Chem. Biol. 2016, 11(1): 172-84, PMC4729198. *Highlighted in Nat. Chem. Biol. 2016.*

Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid

Gupta, V.; Carroll, K. S. Chem. Sci. 2016, 7(1): 400-15, PMC4724439.

The expanding landscape of the thiol redox proteome

Yang. J.; Carroll, K. S.; Liebler, D. C. Mol. Cell Proteomics 2016, 15(1): 1-11, PMC4762510.

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Hello, We're the Carroll Lab

Kate S. Carroll
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Kate S. Carroll

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Christina Dreyton

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Roberta Farina

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Mauro Lo Conte

Youngeun Jung

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Yunlong Shi

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Youai Hao

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Salma Akter

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Darren Turner